We treated aged monkeys with a dose of the longevity factor klotho, which is known to increase synaptic and cognitive functions in mice. We found that a relatively low dose of klotho enhanced cognition in aged monkeys. These findings are important because they suggest that klotho replenishment could prove to be therapeutic in aging humans.
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References
Semba, R. D. et al. Plasma klotho and mortality risk in older community-dwelling adults. J. Gerontol. A Biol. Sci. Med. Sci. 66, 794–800 (2011). This paper reports that klotho levels decrease with human aging.
Dubal, D. B. et al. Life extension factor klotho enhances cognition. Cell Rep. 7, 1065–076 (2014). This paper reports that transgenic overexpression of klotho enhances cognition in mice and that a genetic variant of klotho in humans associates with higher klotho levels and better cognition in aging individuals.
Dubal, D. B. et al. Life extension factor klotho prevents mortality and enhances cognition in hAPP transgenic mice. J. Neurosci. 35, 2358–2371 (2015). This paper reports that transgenic overexpression of klotho improves cognitive deficits in a mouse model of Alzheimer’s disease.
Leon, J. et al. Peripheral elevation of a klotho fragment enhances brain function and resilience in young, aging, and alpha-synuclein transgenic mice. Cell Rep. 20, 1360–1371 (2017). This paper reports that systemic treatment with klotho enhances cognition in young and aging mice, and in mice that model Parkinson’s disease.
Gupta, S. et al. KL1 domain of longevity factor klotho mimics the metabolome of cognitive stimulation and enhances cognition in young and aging mice. J. Neurosci. 42, 4016–4025 (2022). This paper reports that systemic treatment with a specific domain of klotho enhances cognition in young and aging mice.
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This is a summary of: Castner, S. A. et al. Longevity factor klotho enhances cognition in aged nonhuman primates. Nat. Aging, https://doi.org/10.1038/s43587-023-00441-x (2023).
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Klotho, a longevity factor, improves cognitive function in aging nonhuman primates. Nat Aging 3, 915–916 (2023). https://doi.org/10.1038/s43587-023-00466-2
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DOI: https://doi.org/10.1038/s43587-023-00466-2
