 Speaker:
Professor Haitao Lu
Precision-Modification Metabolomics, Chemical Biology, Microbial Metabolism
Shanghai Jiao Tong University
Read more about the speaker and this seminar.
In vivo small molecules as necessary intermediates are involved in numerous critical metabolic pathways and biological processes associated with many essential biological functions and events [1, 2].
In recent years, there is growing evidence to manifest that metabolomics is emerging as a powerful tool for facilitating the discovery of functional small molecules which provides novel insights into a diversity of biological concerns involving disease diagnosis, therapeutic discovery and toxicology [3,4].
Yet, metabolomics holds promise in promoting widely biological innovations in a real world besides terming biomedical niche, which also yields a wealth of information about food and environmental questions concerning safety and toxicology.
In this proposed presentation, brief introduction to metabolomics science shall be given to highlight its concept, protocol, manipulation and biological application for the first instance, and then a line of typical examples will be adopted to demonstrate how metabolomics combining with genetic strategy was employed by my group to facilitate the discovery of functional small molecules whose pattern changes can efficiently delineates the complex mechanisms implicated in a diversity of biological events via targeting the most affected metabolic pathways, such as disease progression, pathogen virulence and discovery and validation of therapeutic targets as well (Figure 1).
References:
[1] W. N. Nie, L. Y. Yan, et al., Mass Spectrometry Reviews., 35, 331-349 (2016).
[2] H. T. Lv, C. S. Hung, et al., Journal of Proteome Research., 13, 1397-1404 (2014).
[3] Q. Su, T. Guan, et al., Scientific Reports., 6, 24099 (2016).
[4] H. T. Lv, Mass Spectrometry Reviews., 32, 118-128 (2013).
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Register here
When
22 August 2017
2-3pm
Venue
Level 6 Seminar room
Charles Perkins Centre
The University of Sydney
NSW 2006
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